Leveraging heterogeneity across multiple datasets increases cell-mixture deconvolution accuracy and reduces biological and technical biases

Cell type deconvolution from bulk expression data rely on a reference expression matrix. Here, the authors introduce a basis matrix built using data from both healthy and diseased samples profiled on 42 platforms, reducing biases introduced by single-platform matrices built using healthy samples.

Detalhes bibliográficos

Principais autores:	Francesco Vallania, Andrew Tam, Shane Lofgren, Steven Schaffert, Tej D. Azad, Erika Bongen, Winston Haynes, Meia Alsup, Michael Alonso, Mark Davis, Edgar Engleman, Purvesh Khatri
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2018-11-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-018-07242-6
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