Role and regulation of Abelson tyrosine kinase in Crk-associated substrate/profilin-1 interaction and airway smooth muscle contraction

Abstract Background Airway smooth muscle contraction is critical for maintenance of appropriate airway tone, and has been implicated in asthma pathogenesis. Smooth muscle contraction requires an “engine” (myosin activation) and a “transmission system” (actin cytoskeletal remodeling). However, the me...

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Hlavní autoři:	Yinna Wang, Alyssa C. Rezey, Ruping Wang, Dale D. Tang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2018-01-01
Edice:	Respiratory Research
Témata:	c-Abl kinase Crk-associated substrate Profilin-1 Smooth muscle Excitation-contraction coupling Actin cytoskeleton
On-line přístup:	http://link.springer.com/article/10.1186/s12931-017-0709-4
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