Snord67 promotes breast cancer metastasis by guiding U6 modification and modulating the splicing landscape

Abstract Previously considered “housekeeping” genes, small nucleolar RNAs (snoRNAs) are increasingly understood to have wide-ranging functions in cancer, yet their role in metastasis has been less well studied. Here, we identify the snoRNA Snord67 as a regulator of lymph node (LN) metastasis in brea...

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Autori principali:	Yvonne L. Chao, Katherine I. Zhou, Kwame K. Forbes, Alessandro Porrello, Gabrielle M. Gentile, Yinzhou Zhu, Aaron C. Chack, Dixcy J. S. John Mary, Haizhou Liu, Eric Cockman, Lincy Edatt, Grant A. Goda, Justin J. Zhao, Hala Abou Assi, Hannah J. Wiedner, Yihsuan Tsai, Lily Wilkinson, Amanda E. D. Van Swearingen, Lisa A. Carey, Jimena Giudice, Daniel Dominguez, Christopher L. Holley, Chad V. Pecot
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2025-05-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-025-59406-w
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