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Impact of common ALDH2 inactivating mutation and alcohol consumption on Alzheimer’s disease

Aldehyde dehydrogenase 2 (ALDH2) is an enzyme found in the mitochondrial matrix that plays a central role in alcohol and aldehyde metabolism. A common ALDH2 polymorphism in East Asians descent (called ALDH2*2 or E504K missense variant, SNP ID: rs671), present in approximately 8% of the world’s popul...

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Bibliografische Detailangaben
Hauptverfasser: Takuya Seike, Che-Hong Chen, Daria Mochly-Rosen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2023-08-01
Schriftenreihe:Frontiers in Aging Neuroscience
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Online-Zugang:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1223977/full
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