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The effect of increased weight loading on body weight is partly dependent on Piezo1 in osteoblast-lineage cells and TrkA signaling

Abstract Obesity is a complex disease driven by multiple factors, and a deeper understanding of its underlying mechanisms could enable the development of novel treatments. Based on our previous experimental studies, we have proposed a homeostatic mechanism regulating adiposity involving mechano-sens...

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Auteurs principaux: Daniel Hägg, Lei Li, Alec T. Beeve, Erica L. Scheller, Jakob Bellman, Fredrik Anesten, Jovana Zlatkovic, Adrià Dalmau Gasull, Ferran Font-Gironès, Sofia Movérare-Skrtic, John-Olov Jansson, Claes Ohlsson
Format: Artigo
Langue:Inglês
Publié: Nature Portfolio 2026-02-01
Collection:Scientific Reports
Accès en ligne:https://doi.org/10.1038/s41598-026-40431-8
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