The Interactome of Palmitoyl-Protein Thioesterase 1 (PPT1) Affects Neuronal Morphology and Function

Palmitoyl-protein thioesterase 1 (PPT1) is a depalmitoylation enzyme that is mutated in cases of neuronal ceroid lipofuscinosis (NCL). The hallmarks of the disease include progressive neurodegeneration and blindness, as well as seizures. In the current study, we identified 62 high-confident PPT1-bin...

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Detalhes bibliográficos

Principais autores:	Tamar Sapir, Michal Segal, Gayane Grigoryan, Karin M. Hansson, Peter James, Menahem Segal, Orly Reiner
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-03-01
coleção:	Frontiers in Cellular Neuroscience
Assuntos:	palmitoyl-protein thioesterase 1 PPT1 hippocampal neurons mass-spectrometry palmitoylation
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fncel.2019.00092/full
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