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Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis

Abstract Cancer cells exhibit distinct metabolic activities and nutritional dependencies compared to normal cells. Thus, characterization of nutrient demands by individual tumor types may identify specific vulnerabilities that can be manipulated to target the destruction of cancer cells. We find tha...

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Principais autores: Niranjan Venkateswaran, Roy Garcia, M. Carmen Lafita-Navarro, Yi-Heng Hao, Lizbeth Perez-Castro, Pedro A. S. Nogueira, Ashley Solmonson, Ilgen Mender, Jessica A. Kilgore, Shun Fang, Isabella N. Brown, Li Li, Emily Parks, Igor Lopes dos Santos, Mahima Bhaskar, Jiwoong Kim, Yuemeng Jia, Andrew Lemoff, Nick V. Grishin, Lisa Kinch, Lin Xu, Noelle S. Williams, Jerry W. Shay, Ralph J. DeBerardinis, Hao Zhu, Maralice Conacci-Sorrell
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2024-05-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-024-47868-3
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