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Unexpected dynamics in femtomolar complexes of binding proteins with peptides

Abstract Ultra-tight binding is usually observed for proteins associating with rigidified molecules. Previously, we demonstrated that femtomolar binders derived from the Armadillo repeat proteins (ArmRPs) can be designed to interact very tightly with fully flexible peptides. Here we show for ArmRPs...

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Principais autores: Stefano Cucuzza, Malgorzata Sitnik, Simon Jurt, Erich Michel, Wenzhao Dai, Thomas Müntener, Patrick Ernst, Daniel Häussinger, Andreas Plückthun, Oliver Zerbe
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Portfolio 2023-11-01
סדרה:Nature Communications
גישה מקוונת:https://doi.org/10.1038/s41467-023-43596-2
תגים: הוספת תג
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