Glymphatic dysfunction impairs cognitive function via disrupted white matter network efficiency in primary insomnia: A DTI-ALPS mediation study

Background: Primary insomnia (PI) is increasingly recognized as a brain network disorder associated with cognitive impairment. Emerging evidence suggests that glymphatic system dysfunction may underlie these deficits by impairing brain clearance mechanisms during sleep. However, the interplay betwee...

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Autors principals:	Chen Wang, Tian Zhang, Huizhen Lu, Ziliang Xu, Shengnan Wei, Chaozong Ma, Peng Fang, Yuanqiang Zhu, Fan Guo
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-12-01
Col·lecció:	Brain Research Bulletin
Matèries:	Primary insomnia Glymphatic system DTI-ALPS Cognitive impairment Graph theory Mediation analysis
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S0361923025004526
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