NMDA receptors are not necessary for burst firing of lateral habenula neurons in mice

BackgroundBurst firing in the lateral habenula (LHb) is enhanced under stress and depression, and ketamine blocks burst firing in LHb to exert a rapid antidepressant effect. Thus, burst firing in LHb may serve as a cellular mechanism of depression and a promising therapeutic target for developing no...

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Autores principales:	Rong Zhou, Jingjing Lu, Yunxiang Ling, Hong Wang, Lijun Cui, Yongliang Pan, Huanxin Chen
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2026-06-01
Colección:	Frontiers in Psychiatry
Materias:	burst firing D-AP5 MK-801 NMDA receptor the lateral habenula T-type calcium channel
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1828920/full
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