Endogenous generation of nitro-fatty acid hybrids having dual nitrate ester (RONO2) and nitroalkene (RNO2) substituents

Organic nitrate esters, long-recognized therapies for cardiovascular disorders, have not been detected biologically. We characterize in rat stomach unsaturated fatty acid nitration reactions that proceed by generation of nitro-nitrate intermediates (NO2–ONO2-FA) via oxygen and nitrite dependent reac...

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Detalhes bibliográficos

Principais autores:	Marco Fazzari, Steven R. Woodcock, Pascal Rowart, Karina Ricart, Jack R. Lancaster, Jr., Rakesh Patel, Dario A. Vitturi, Bruce A. Freeman, Francisco J. Schopfer
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-05-01
coleção:	Redox Biology
Assuntos:	Nitro-nitrate-fatty acid Nitro-conjugated linoleic acid Conjugated linoleic acid Fatty acid nitroalkene Nitrate ester
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213231721000616
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