Targeting the NLRP3 inflammasome in cochlear macrophages protects against hearing loss in chronic suppurative otitis media

Abstract The activation of the NLRP3 inflammasome has been linked to several inflammatory and autoinflammatory diseases. Despite cases of potential hearing improvement in immune-mediated diseases, direct evidence of the efficacy of targeting this mechanism in the inner ear is still lacking. Previous...

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Hauptverfasser:	Viktoria Schiel, Ritwija Bhattacharya, Ankur Gupta, Kourosh Eftekharian, Anping Xia, Peter L Santa Maria
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-09-01
Schriftenreihe:	Journal of Neuroinflammation
Schlagworte:	Chronic suppurative otitis media Sensorineural hearing loss Inflammation macrophages NLRP3
Online-Zugang:	https://doi.org/10.1186/s12974-024-03212-6
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