Peripheral monocytes from Crohn’s disease patients retain functional responsiveness to GM-CSF during active disease

IntroductionCrohn’s disease (CD) is a relapsing inflammatory disease that is currently not curable. Despite the availability of anti-inflammatory treatments, 30–60% of patients develop resistance, necessitating the need for novel therapeutic approaches. Data from colitis models in mice indicate that...

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Principais autores:	Paul P. Winkel, Wendy Bergmann-Ewert, Johannes Reiner, Astrid Huth, Dana Kleimeier, Rosaely Casalegno Garduño, Ida M. Wrobel, Grazyna Domanska, Jan Däbritz, Elisa Wirthgen
格式:	Artigo
語言:	Inglês
出版:	Frontiers Media S.A. 2025-09-01
叢編:	Frontiers in Immunology
主題:	Crohn’s disease monocytes cellular therapy granulocyte-macrophage colony-stimulating factor cytokine innate immunity
在線閱讀:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1663713/full
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