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Ca2+ mobilization-dependent reduction of the endoplasmic reticulum lumen is due to influx of cytosolic glutathione

Abstract Background The lumen of the endoplasmic reticulum (ER) acts as a cellular Ca2+ store and a site for oxidative protein folding, which is controlled by the reduced glutathione (GSH) and glutathione-disulfide (GSSG) redox pair. Although depletion of luminal Ca2+ from the ER provokes a rapid an...

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Principais autores: Beáta Lizák, Julia Birk, Melinda Zana, Gergely Kosztyi, Denise V. Kratschmar, Alex Odermatt, Richard Zimmermann, Miklós Geiszt, Christian Appenzeller-Herzog, Gábor Bánhegyi
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2020-02-01
Series:BMC Biology
Assuntos:
Endoplasmic reticulum
Endoplasmic reticulum stress
Redox homeostasis
Glutathione
Calcium
Sec61 translocon
Acceso en liña:http://link.springer.com/article/10.1186/s12915-020-0749-y
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