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Targeted Chromosomal Barcoding Establishes Direct Genotype-Phenotype Associations for Antibiotic Resistance in Mycobacterium abscessus

ABSTRACT A bedaquiline-resistant Mycobacterium abscessus isolate was sequenced, and a candidate mutation in the atpE gene was identified as responsible for the antibiotic resistance phenotype. To establish a direct genotype-phenotype relationship of this mutation which results in a Asp-to-Ala change...

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Principais autores: Juan Calvet-Seral, Estefanía Crespo-Yuste, Vanessa Mathys, Hector Rodriguez-Villalobos, Pieter-Jan Ceyssens, Anandi Martin, Jesús Gonzalo-Asensio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2023-06-01
coleção:Microbiology Spectrum
Assuntos:
bedaquiline
Bq
Bdq
drug resistance
nontuberculous mycobacteria
cystic fibrosis
Acesso em linha:https://journals.asm.org/doi/10.1128/spectrum.05344-22
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