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CD94/NKG2A-Qa-1b axis as a key modulator of vaccine responsiveness in aging populations

Summary: Vaccine responses decline with age, yet the underlying mechanisms remain unclear. Using an aluminum hydroxide (Alum)-adjuvanted spike (S+Alum) vaccine, this study identifies an aging-linked pathway in which senescence-associated secretory phenotype (SASP) cytokines (C-C motif chemokine liga...

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Principais autores: Li Chen, Ziyi Bai, Dandan Wan, Wenyan Ren, Haiying Que, Jiayu Wang, Yishan Lu, Xuemei He, Weiqi Hong, Aqu Alu, Dandan Peng, Minyang Fu, Yuhe Huang, Jiayuan Ai, Qiaonan Hong, Hantai Tan, Zirui Gao, Xinyu Tian, Cong Tang, Yanan Zhou, Shuaiyao Lu, Xiaohe Tian, Xiawei Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-11-01
coleção:Cell Reports
Assuntos:
CP: Immunology
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124725012859
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