Enhanced Efficacy of a Codon-Optimized DNA Vaccine Encoding the Glycoprotein Precursor Gene of Lassa Virus in a Guinea Pig Disease Model When Delivered by Dermal Electroporation

Lassa virus (LASV) causes a severe, often fatal, hemorrhagic fever endemic to West Africa. Presently, there are no FDA-licensed medical countermeasures for this disease. In a pilot study, we constructed a DNA vaccine (pLASV-GPC) that expressed the LASV glycoprotein precursor gene (GPC). This plasmid...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Niranjan Y. Sardesai, Connie S. Schmaljohn, Catherine V. Badger, Mary C. Guttieri, Kristin W. Spik, Carl I. Shaia, Amy C. Shurtleff, Todd M. Bell, Kate E. Broderick, Eric R. Wilkinson, Kathleen A. Cashman
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	MDPI AG 2013-07-01
סדרה:	Vaccines
נושאים:	Lassa fever Lassa virus arenavirus guinea pigs dermal electroporation vaccination vaccine
גישה מקוונת:	http://www.mdpi.com/2076-393X/1/3/262
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!