Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG

Abstract Background The histone variant H3.3 K27M mutation is a defining characteristic of diffuse intrinsic pontine glioma (DIPG)/diffuse midline glioma (DMG). This histone mutation is responsible for major alterations to histone H3 post-translational modification (PTMs) and subsequent aberrant gen...

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Autori principali:	Nichole A. Lewis, Rachel Herndon Klein, Cailin Kelly, Jennifer Yee, Paul S. Knoepfler
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2022-05-01
Serie:	Epigenetics & Chromatin
Soggetti:	ATAC-seq ASCL1 NEUROD1 diffuse midline glioma Super-enhancers Epigenetics
Accesso online:	https://doi.org/10.1186/s13072-022-00447-6
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