Design, Synthesis and Biological Evaluation of Novel <i>1H</i>-benzo[d]imidazole Derivatives as Fatty Acid Synthase (FASN) Inhibitors for Cancer Treatment

FASN is a metabolic oncoprotein that is overexpressed in multiple cancers and regulates the fatty acid requirements of proliferating cells. Thus, FASN has been proposed as a promising target for anticancer drug discovery. Herein, we report the <i>de novo</i> design and synthesis of small-molecule FA...

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Ngā kaituhi matua:	Shailendra Singh, Subarno Paul, Chandrabose Karthikeyan, Natércia F. Brás, Chanakya Nath Kundu, Narayana Subbiah Hari Narayana Moorthy
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2022-11-01
Rangatū:	Medical Sciences Forum
Ngā marau:	fatty acid synthase inhibitor cancer apoptosis cell cycle enzyme inhibition MD simulation
Urunga tuihono:	https://www.mdpi.com/2673-9992/14/1/117
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!