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The liver pharmacological and xenobiotic gene response repertoire

Abstract We have used a supervised classification approach to systematically mine a large microarray database derived from livers of compound‐treated rats. Thirty‐four distinct signatures (classifiers) for pharmacological and toxicological end points can be identified. Just 200 genes are sufficient...

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Principais autores: Georges Natsoulis, Cecelia I Pearson, Jeremy Gollub, Barrett P Eynon, Joe Ferng, Ramesh Nair, Radha Idury, May D Lee, Mark R Fielden, Richard J Brennan, Alan H Roter, Kurt Jarnagin
Format: Artigo
Sprog:Inglês
Udgivet: Springer Nature 2008-03-01
Serier:Molecular Systems Biology
Fag:
biomarker
data mining
liver
toxicity
toxicology
xenobiotic
Online adgang:https://doi.org/10.1038/msb.2008.9
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