Structures of HIV-1 Neutralizing Antibody 10E8 Delineate the Mechanistic Basis of Its Multi-Peak Behavior on Size-Exclusion Chromatography

Antibody 10E8 is capable of effectively neutralizing HIV through its recognition of the membrane-proximal external region (MPER), and a suitably optimized version of 10E8 might have utility in HIV therapy and prophylaxis. However, 10E8 displays a three-peak profile on size-exclusion chromatography (...

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Hlavní autoři:	Young Do Kwon, Xiangchun E. Wang, Michael F. Bender, Rong Yang, Yile Li, Krisha McKee, Reda Rawi, Sijy O’Dell, Nicole A. Schneck, Andrew Shaddeau, Baoshan Zhang, Frank J. Arnold, Mark Connors, Nicole A. Doria-Rose, Peter D. Kwong, Q. Paula Lei
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2021-06-01
Edice:	Antibodies
Témata:	cis-trans proline isomerization conformational isomerization hydrophobic interaction chromatography (HIC) mobile phase modifier monoclonal antibody 10E8 MPER
On-line přístup:	https://www.mdpi.com/2073-4468/10/2/23
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