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A DIseAse MOdule Detection (DIAMOnD) algorithm derived from a systematic analysis of connectivity patterns of disease proteins in the human interactome.

The observation that disease associated proteins often interact with each other has fueled the development of network-based approaches to elucidate the molecular mechanisms of human disease. Such approaches build on the assumption that protein interaction networks can be viewed as maps in which dise...

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Bibliografiske detaljer
Principais autores: Susan Dina Ghiassian, Jörg Menche, Albert-László Barabási
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2015-04-01
Serier:PLoS Computational Biology
Online adgang:https://doi.org/10.1371/journal.pcbi.1004120
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