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Selective androgen receptor degrader (SARD) to overcome antiandrogen resistance in castration-resistant prostate cancer

In patients with castration-resistant prostate cancer (CRPC), clinical resistances such as androgen receptor (AR) mutation, AR overexpression, and AR splice variants (ARVs) limit the effectiveness of second-generation antiandrogens (SGAs). Several strategies have been implemented to develop novel an...

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Principais autores: Meng Wu, Rongyu Zhang, Zixiong Zhang, Ning Zhang, Chenfan Li, Yongli Xie, Haoran Xia, Fangjiao Huang, Ruoying Zhang, Ming Liu, Xiaoyu Li, Shan Cen, Jinming Zhou
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2023-01-01
Serier:eLife
Fag:
androgen receptor
degrader
antiandrogen
enzalutamide resistance
castration-resistant prostate cancer
Online adgang:https://elifesciences.org/articles/70700
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