Plexin-Semaphorin Signaling Modifies Neuromuscular Defects in a Drosophila Model of Peripheral Neuropathy

Dominant mutations in GARS, encoding the ubiquitous enzyme glycyl-tRNA synthetase (GlyRS), cause peripheral nerve degeneration and Charcot-Marie-Tooth disease type 2D (CMT2D). This genetic disorder exemplifies a recurring paradigm in neurodegeneration, in which mutations in essential genes cause sel...

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखकों:	Stuart J. Grice, James N. Sleigh, M. Zameel Cader
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Frontiers Media S.A. 2018-02-01
श्रृंखला:	Frontiers in Molecular Neuroscience
विषय:	axonal guidance aminoacyl-tRNA synthetase (ARS) Charcot-Marie-Tooth disease type 2D (CMT2D) distal spinal muscular atrophy type V (dSMA-V) GARS glycyl-tRNA synthetase
ऑनलाइन पहुंच:	http://journal.frontiersin.org/article/10.3389/fnmol.2018.00055/full
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