Design, synthesis, and evaluation of novel stilbene derivatives that degrade acidic nucleoplasmic DNA-binding protein 1 (And1) and synergize with PARP1 inhibitor in NSCLC cells

Specifically inducing the degradation of acidic nucleoplasmic DNA-binding protein 1 (And1) is a promising antitumor strategy. Our previous study identified Bazedoxifene (BZA) and CH3 as specific And1 degraders and validated their activity in reversing radiotherapy resistance in vitro and in vivo. Ho...

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Bibliografische Detailangaben

Hauptverfasser:	Leyuan Chen, Zhonghao Ren, Yunze Zhang, Wenbin Hou, Yiliang Li
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis Group 2024-12-01
Schriftenreihe:	Journal of Enzyme Inhibition and Medicinal Chemistry
Schlagworte:	And-1(WDHD1) DNA damage response antitumor synthetic lethal
Online-Zugang:	https://www.tandfonline.com/doi/10.1080/14756366.2024.2383886
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