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Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer’s Disease Pathogenesis

Neurons are highly specialized post-mitotic cells that are inherently dependent on mitochondria owing to their high bioenergetic demand. Mitochondrial dysfunction is therefore associated with various age-related neurodegenerative disorders such as Alzheimer’s disease (AD), wherein accumulation of da...

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Autori principali: Anushka Chakravorty, Cuckoo Teresa Jetto, Ravi Manjithaya
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019-11-01
Serie:Frontiers in Aging Neuroscience
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Accesso online:https://www.frontiersin.org/article/10.3389/fnagi.2019.00311/full
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