A Tailored Strategy to Crosslink the Aspartate Transcarbamoylase Domain of the Multienzymatic Protein CAD

CAD is a 1.5 MDa hexameric protein with four enzymatic domains responsible for initiating de novo biosynthesis of pyrimidines nucleotides: glutaminase, carbamoyl phosphate synthetase, aspartate transcarbamoylase (ATC), and dihydroorotase. Despite its central metabolic role and implication in cancer...

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Autors principals:	Francisco del Caño-Ochoa, Antonio Rubio-del-Campo, Santiago Ramón-Maiques
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2023-01-01
Col·lecció:	Molecules
Matèries:	nucleotide metabolism de novo pyrimidine biosynthesis carbamoyl-phosphate synthetase dihydroorotase cysteine disulfide bridge
Accés en línia:	https://www.mdpi.com/1420-3049/28/2/660
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