Loss of PIK3CA Allows <i>In Vitro</i> Growth but Not <i>In Vivo</i> Progression of KRAS Mutant Lung Adenocarcinoma in a Syngeneic Orthotopic Implantation Model

Constitutively active KRAS mutations are highly prevalent in lung cancers, but the direct role of its downstream phosphatidylinositol 3-kinase (PI3K) pathway in tumor progression remains unclear. A previous study established the requirement for PIK3CA, the alpha catalytic isoform, in lung tumor deve...

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Detalhes bibliográficos

Principais autores:	Abigail L. Booth, Giuseppe Caso, Barbara Rosati, Ya-Ping Jiang, Wei-Xing Zong, Richard Z. Lin, Harold Bien
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-03-01
coleção:	Cells
Assuntos:	PIK3CA STK11 lung cancer LUAD KRAS orthotopic model
Acesso em linha:	https://www.mdpi.com/2073-4409/15/6/506
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