Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression

Abstract Background Prostate cancer is caused by genomic aberrations in normal epithelial cells, however clinical translation of findings from analyses of cancer cells alone has been very limited. A deeper understanding of the tumour microenvironment is needed to identify the key drivers of disease...

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Principais autores:	Stefano Mangiola, Patrick McCoy, Martin Modrak, Fernando Souza-Fonseca-Guimaraes, Daniel Blashki, Ryan Stuchbery, Simon P. Keam, Michael Kerger, Ken Chow, Chayanica Nasa, Melanie Le Page, Natalie Lister, Simon Monard, Justin Peters, Phil Dundee, Scott G. Williams, Anthony J. Costello, Paul J. Neeson, Bhupinder Pal, Nicholas D. Huntington, Niall M. Corcoran, Anthony T. Papenfuss, Christopher M. Hovens
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2021-07-01
Series:	BMC Cancer
Assuntos:	Prostate cancer Transcriptomics FACS Immunohistochemistry Deconvolution Bayes
Acceso en liña:	https://doi.org/10.1186/s12885-021-08529-6
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