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Identification of BACE2 as an avid ß-amyloid-degrading protease

<p>Abstract</p> <p>Background</p> <p>Proteases that degrade the amyloid ß-protein (Aß) have emerged as key players in the etiology and potential treatment of Alzheimer’s disease (AD), but it is unlikely that all such proteases have been identified. To discover new Aß-degrading proteases (AßDPs), we...

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Sparad:
Huvudupphov: Abdul-Hay Samer O, Sahara Tomoko, McBride Melinda, Kang Dongcheul, Leissring Malcolm A
Materialtyp: Artigo
Språk:Inglês
Utgiven: BMC 2012-09-01
Serie:Molecular Neurodegeneration
Ämnen:
Amyloid-ß-protein
Alzheimer disease
ß-site APP-cleaving enzyme-1
ß-site APP-cleaving enzyme-2
Functional screen
Gene therapy
Protease
Proteolytic degradation
Länkar:http://www.molecularneurodegeneration.com/content/7/1/46
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