Identification and validation of SQLE in steroid-induced osteonecrosis of the femoral head: a bioinformatics and experimental study

Abstract Background Osteonecrosis of the femoral head (ONFH) is a prevalent and refractory hip disease. In this study, we investigated the expression profiles of lipid metabolism-related genes in ONFH and evaluated the potential therapeutic effects of squalene epoxidase (SQLE) and its inhibitors. Me...

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Main Authors: Yixiang He, Wanjia Qiao, Kui Zhang, Xuewen Shi, Wenji Wang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-10-01
Serier:Journal of Orthopaedic Surgery and Research
Fag:
Osteonecrosis of the femoral head
Lipid metabolism
Bioinformatics
Transcriptome sequencing
Squalene epoxidase
Terbinafine
Online adgang:https://doi.org/10.1186/s13018-025-06305-x
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