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LSD1 Inhibition Enhances the Immunogenicity of Mesenchymal Stromal Cells by Eliciting a dsRNA Stress Response

Mesenchymal stromal cells (MSCs) are commonly known for their immune-suppressive abilities. However, our group provided evidence that it is possible to convert MSCs into potent antigen presenting cells (APCs) using either genetic engineering or pharmacological means. Given the capacity of UM171a to...

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Principais autores: Fatemeh Mardani, Wael Saad, Nehme El-Hachem, Jean-Pierre Bikorimana, Mazen Kurdi, Riam Shammaa, Sebastien Talbot, Moutih Rafei
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-06-01
Serier:Cells
Fag:
mesenchymal stromal cells
antigen presentation
LSD1
tranylcypromine
UM171a
dsRNA
Online adgang:https://www.mdpi.com/2073-4409/11/11/1816
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