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ACSL4 knockdown inhibits colorectal cancer progression through stimulating anti-tumor immunity

Background: Long-chain acyl-CoA synthetase 4 (ACSL4), a crucial modulator of ferroptosis, is associated with tumor progression, though its impact on colorectal cancer (CRC) immune dynamics is not fully understood.Methods: ACSL4 expression was analyzed in CRC tissues and correlated with patient progn...

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Autori principali: Yiming Liu, Xingyu Jiang, Dongquan Jing, Yanting Lin, Rui Gao, Qixiang Zhao, Huijuan Da, Yiming Ren, Qiuhua Cao, Ning Liu, Xiaoyun Han, Juan Du, Xinghua Gao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2025-09-01
Serie:Neoplasia: An International Journal for Oncology Research
Soggetti:
ACSL4
Tumor immunity
Colorectal cancer
RIG-I-MAVS
Type I Interferon
Accesso online:http://www.sciencedirect.com/science/article/pii/S1476558625000740
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