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Chiral Pyrazolo[4,3-<i>e</i>][1,2,4]triazine Sulfonamides—Their Biological Activity, Lipophilicity, Protein Affinity, and Metabolic Transformations

Referring to our previous laboratory results related to the tyrosinase and urease inhibition by pyrazolo[4,3-<i>e</i>][1,2,4]triazine sulfonamides, we examined here in silico the mechanism of action at the molecular level of the investigated pyrazolotriazine sulfonamides by the molecular docking met...

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Principais autores: Zofia Bernat, Anna Mieszkowska, Zofia Mazerska, Joanna Matysiak, Zbigniew Karczmarzyk, Katarzyna Kotwica-Mojzych, Mariusz Mojzych
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-03-01
Serier:Applied Sciences
Fag:
pyrazolo[4,3-<i>e</i>][1,2,4]triazine sulfonamides
tyrosinase inhibitors
urease inhibitors
molecular docking
affinity chromatography
Online adgang:https://www.mdpi.com/2076-3417/11/6/2660
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