Neutrophil Elastase Increases Vascular Permeability and Leukocyte Transmigration in Cultured Endothelial Cells and Obese Mice

Neutrophil elastase (NE) plays a pivotal role in inflammation. However, the mechanism underlying NE-mediated inflammation in obesity remains unclear. Here, we report that NE activates protease-activated receptor-2 (PAR2), stimulates actin filament (F-actin) formation, decreases intercellular junctio...

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Auteurs principaux:	Chinchu Jagadan Ushakumari, Qiong L. Zhou, Yu-Hua Wang, Sijia Na, Michael C. Rigor, Cindy Y. Zhou, Max K. Kroll, Benjamin D. Lin, Zhen Y. Jiang
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2022-07-01
Collection:	Cells
Sujets:	neutrophil elastase vascular endothelial injury obesity neutrophils systemic inflammation
Accès en ligne:	https://www.mdpi.com/2073-4409/11/15/2288
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