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Targeting the NANOG/HDAC1 axis reverses resistance to PD-1 blockade by reinvigorating the antitumor immunity cycle

Immune checkpoint blockade (ICB) therapy has shifted the paradigm for cancer treatment. However, the majority of patients lack effective responses because of the emergence of immune-refractory tumors that disrupt the amplification of antitumor immunity. Therefore, the identification of clinically av...

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Principais autores: Se Jin Oh, Hyo-Jung Lee, Kwon-Ho Song, Suyeon Kim, Eunho Cho, Jaeyoon Lee, Marcus W. Bosenberg, Tae Woo Kim
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2022-03-01
Serier:The Journal of Clinical Investigation
Fag:
Oncology
Therapeutics
Online adgang:https://doi.org/10.1172/JCI147908
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