Newly Identified Transcriptomic Biomarkers and Gene Signature of Pathological Complete Response to Induction Chemoimmunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma

ABSTRACT Neoadjuvant therapies incorporating immune checkpoint inhibitors (ICIs) have shown promise in locally advanced head and neck squamous cell carcinoma (HNSCC). However, biomarkers for pathological complete response (pCR) remain undefined. In the CheckRad‐CD8 trial (NCT03426657), we performed...

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Autors principals:	Jian‐Guo Zhou, Markus Eckstein, Haitao Wang, Tianjun Lan, Benjamin Frey, Xin Li, Xiaofan Lu, Gunther Klautke, Thomas Illmer, Maximilian Fleischmann, Simon Laban, Matthias G. Hautmann, Bálint Tamaskovics, Thomas B. Brunner, Arndt Hartmann, Rainer Fietkau, Hu Ma, Antoniu‐Oreste Gostian, Heinrich Iro, Markus Hecht, Udo S. Gaipl
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2026-01-01
Col·lecció:	MedComm
Matèries:	head and neck squamous cell carcinoma immunotherapy induction therapy pathological complete response transcriptomic biomarkers
Accés en línia:	https://doi.org/10.1002/mco2.70582
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