Synthesis, characterization, molecular docking, in silico ADME study, and in vitro cytotoxicity evaluation of new pyridine derivatives of nabumetone.

New pyridine derivatives of nabumetone containing 2-amino 3-cyano moieties were synthesized and aimed to introduce new EGFR kinase inhibitors through two methods either by synthesis of chalcone derivatives initially (1a-d) followed by reacting it with malononitrile and ammonium acetate to form (...

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Auteurs principaux:	Bushra K. Jameel, Ayad Mohammed Rasheed Raauf, Wassan Abdul Kareem Abbas
Format:	Artigo
Langue:	Inglês
Publié:	College of Pharmacy / Mustansiriyah University 2023-07-01
Collection:	Al-Mustansiriyah Journal of Pharmaceutical Sciences
Sujets:	Nabumetone, EGFR inhibitor, cyanopyridine, anticancer, molecular docking
Accès en ligne:	https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1042
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