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The role of circulating monocytes and JAK inhibition in the infectious-driven inflammatory response of myelofibrosis

Myelofibrosis (MF) is characterized by chronic inflammation and hyper-activation of the JAK-STAT pathway. Infections are one of the main causes of morbidity/mortality. Therapy with Ruxolitinib (RUX), a JAK1/2 inhibitor, may further increase the infectious risk. Monocytes are critical players in infl...

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Principais autores: Martina Barone, Lucia Catani, Francesca Ricci, Marco Romano, Dorian Forte, Giuseppe Auteri, Daniela Bartoletti, Emanuela Ottaviani, Pier Luigi Tazzari, Nicola Vianelli, Michele Cavo, Francesca Palandri
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2020-01-01
coleção:OncoImmunology
Assuntos:
myelofibrosis
monocyte
ruxolitinib
extracellular vesicles
Acesso em linha:http://dx.doi.org/10.1080/2162402X.2020.1782575
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