Obicetrapib exhibits favorable physiochemical and pharmacokinetic properties compared to previous cholesteryl ester transfer protein inhibitors: An integrated summary of results from non‐human primate studies and clinical trials

Abstract Anacetrapib, a cholesteryl ester transfer protein (CETP) inhibitor previously under development, exhibited an usually extended terminal half‐life and large food effect and accumulated in adipose tissue. Other CETP inhibitors have not shown such effects. Obicetrapib, a potent selective CETP...

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Principais autores:	Stephen J. Nicholls, Adam J. Nelson, John J. P. Kastelein, Marc Ditmarsch, Andrew Hsieh, Judith Johnson, Danielle Curcio, Douglas Kling, Carol F. Kirkpatrick, Michael H. Davidson
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Wiley 2024-12-01
סדרה:	Pharmacology Research & Perspectives
נושאים:	accumulation anacetrapib cholesteryl ester transfer protein elimination obicetrapib pharmacokinetics
גישה מקוונת:	https://doi.org/10.1002/prp2.70010
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!