Diacylglycerol Kinase ζ Attenuates Doxorubicin‐Induced Cardiotoxicity Through p53 Degradation

Background Doxorubicin‐induced cardiotoxicity is still an important medical problem associated with a high mortality rate in cancer survivors. p53 plays a key role in doxorubicin‐induced cardiotoxicity. Diacylglycerol kinase ζ (Dgkζ), a 130‐kDa enzyme abundant in cardiomyocytes, regulates the p53 pr...

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Principais autores:	Shingo Tachibana, Yoichiro Otaki, Tetsu Watanabe, Jun Goto, Haruki Ochi, Toshiaki Tanaka, Hiroe Ono, Ryuhei Yamaguchi, Junya Sato, Hiroki Takahashi, Takanori Arimoto, Kaoru Goto, Masafumi Watanabe
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2025-01-01
Serija:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Teme:	chip Dgkζ doxorubicin cardiotoxicity E6ap Hsp70 p53
Online dostop:	https://www.ahajournals.org/doi/10.1161/JAHA.124.035608
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