Multi-omics analyses of MEN1 missense mutations identify disruption of menin–MLL and menin–JunD interactions as critical requirements for molecular pathogenicity

Abstract Background Loss-of-function mutations of the multiple endocrine neoplasia type 1 (MEN1) gene are causal to the MEN1 tumor syndrome, but they are also commonly found in sporadic pancreatic neuroendocrine tumors and other types of cancers. The MEN1 gene product, menin, is involved in transcri...

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Hlavní autoři:	Koen M. A. Dreijerink, Ezgi Ozyerli-Goknar, Stefanie Koidl, Ewoud J. van der Lelij, Priscilla van den Heuvel, Jeffrey J. Kooijman, Martin L. Biniossek, Kees W. Rodenburg, Sheikh Nizamuddin, H. T. Marc Timmers
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2022-08-01
Edice:	Epigenetics & Chromatin
Témata:	Tumor suppressor MEN1 syndrome Histone H3K4 methylation AP-1 transcription factors ATF transcription factors Quantitative mass spectrometry
On-line přístup:	https://doi.org/10.1186/s13072-022-00461-8
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