Comparison of the pharmacokinetic profiles of three triterpenoids after oral administration of a cucurbitacin tablet and nanosuspension by UHPLC-MS/MS

IntroductionCucurbitacin, a class of triterpenoid compounds isolated from Pedicellus Melo, possesses various biological activities and is the primary active component of cucurbitacin tablets (CUT) used to treat chronic hepatitis and primary liver cancer. Nanosuspensions can potentially improve the o...

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Principais autores:	Chun-nan Zhang, Zhi-bin Wang, Rui-tong Du, Shu-lu Zhang, Chu-qiao Wang, Meng Wang, Li-hong Wu, De-qiang Yang, Chen Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-09-01
coleção:	Frontiers in Pharmacology
Assuntos:	cucurbitacin nanosuspension pharmacokinetic rat plasma UHPLC-MS/MS
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1647015/full
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