Development and Validation of a Long-Term 3D Glioblastoma Cell Culture in Alginate Microfibers as a Novel Bio-Mimicking Model System for Preclinical Drug Testing

Background: Various three-dimensional (3D) glioblastoma cell culture models have a limited duration of viability. Our aim was to develop a long-term 3D glioblastoma model, which is necessary for reliable drug response studies. Methods: Human U87 glioblastoma cells were cultured in alginate microfibe...

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Bibliografische Detailangaben

Hauptverfasser:	Miodrag Dragoj, Jasmina Stojkovska, Tijana Stanković, Jelena Dinić, Ana Podolski-Renić, Bojana Obradović, Milica Pešić
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-07-01
Schriftenreihe:	Brain Sciences
Schlagworte:	glioblastoma 3D cell culture alginate hydrogel temozolomide drug resistance
Online-Zugang:	https://www.mdpi.com/2076-3425/11/8/1025
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