m6A methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis

The roles of nuclear receptor subfamily 1 group d member 1 (NR1D1) and the circadian clock in liver fibrosis remain unclear. Here, we showed that liver clock genes, especially NR1D1, were dysregulated in mice with carbon tetrachloride (CCl4)-induced liver fibrosis. In turn, disruption of the circadi...

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Prif Awduron:	Li Chen, Siwei Xia, Feixia Wang, Yuanyuan Zhou, Shuqi Wang, Ting Yang, Yang Li, Min Xu, Ya Zhou, Desong Kong, Zili Zhang, Jiangjuan Shao, Xuefen Xu, Feng Zhang, Shizhong Zheng
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Elsevier 2023-03-01
Cyfres:	Pharmacological Research
Pynciau:	Liver fibrosis Circadian clock Primary hepatic stellate cell NR1D1 M6A Mitochondrial dynamics
Mynediad Ar-lein:	http://www.sciencedirect.com/science/article/pii/S1043661823000609
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!