Preclinical validation of human recombinant glutamate-oxaloacetate transaminase for the treatment of acute ischemic stroke

Summary: The blood enzyme glutamate-oxaloacetate transaminase (GOT) has been postulated as an effective therapeutic to protect the brain during stroke. To demonstrate its potential clinical utility, a new human recombinant form of GOT (rGOT) was produced for medical use.We tested the pharmacokinetic...

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Principais autores:	María Pérez-Mato, Antonio Dopico-López, Yunus Akkoc, Sonia López-Amoedo, Clara Correa-Paz, María Candamo-Lourido, Ramón Iglesias-Rey, Esteban López-Arias, Ana Bugallo-Casal, Andrés da Silva-Candal, Susana B. Bravo, María del Pilar Chantada-Vázquez, Susana Arias, María Santamaría-Cadavid, Ana Estany-Gestal, Ahlem Zaghmi, Marc A. Gauthier, María Gutiérrez-Fernández, Abraham Martin, Jordi Llop, Cristina Rodríguez, Ángeles Almeida, Martina Migliavacca, Ester Polo, Beatriz Pelaz, Devrim Gozuacik, Naouale El Yamani, Tanima SenGupta, Elise Rundén-Pran, José Vivancos, Mar Castellanos, Exuperio Díez-Tejedor, Tomás Sobrino, Aharon Rabinkov, David Mirelman, José Castillo, Francisco Campos
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2024-11-01
Serija:	iScience
Teme:	biological sciences natural sciences neuroscience pharmacology physiology
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2589004224023332
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