Type I Interferon Supports Inducible Nitric Oxide Synthase in Murine Hepatoma Cells and Hepatocytes and during Experimental Acetaminophen-Induced Liver Damage

Cytokine regulation of high-output nitric oxide (NO) derived from inducible NO synthase (iNOS) is critically involved in inflammation biology and host defense. Herein, we set out to characterize the role of type I interferon (IFN) as potential regulator of hepatic iNOS in vitro and in vivo. In this...

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Autori principali:	Malte Bachmann, Zoe Waibler, Thomas Pleli, Josef Pfeilschifter, Heiko Mühl
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2017-07-01
Serie:	Frontiers in Immunology
Soggetti:	type I interferon inducible nitric oxide synthase signal transducer and activator of transcription-1 acetaminophen liver damage
Accesso online:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00890/full
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