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Ginsenoside Rg3 in combination with artesunate overcomes sorafenib resistance in hepatoma cell and mouse models

Background: Sorafenib is effective in treating hepatoma, but most patients develop resistance to it. STAT3 signaling has been implicated in sorafenib resistance. Artesunate (ART) and 20(R)-ginsenoside Rg3 (Rg3) have anti-hepatoma effects and can inhibit STAT3 signaling in cancer cells. This study ai...

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Principais autores: Ying-Jie Chen, Jia-Ying Wu, Yu-Yi Deng, Ying Wu, Xiao-Qi Wang, Amy Sze-man Li, Lut Yi Wong, Xiu-Qiong Fu, Zhi-Ling Yu, Chun Liang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2022-05-01
Serier:Journal of Ginseng Research
Fag:
Artesunate
Ginsenoside Rg3
Hepatoma
Sorafenib resistance
STAT3 signaling
Online adgang:http://www.sciencedirect.com/science/article/pii/S1226845321001068
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