G2019s LRRK2 promotes mitochondrial fission and increases TNFα-mediated neuroinflammation responses

Leucine rich-repeat kinase 2 (LRRK2) is involved in the pathogenesis of Parkinson’s disease (PD). LRRK2 has kinase and GTPase activities, and mediates several cell functions, including vesicle trafficking, apoptosis, autophagy, mitochondrial dynamics, and neuroinflammation. G2019S (GS) is the most p...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Dong Hwan Ho, Heajin Lee, Ilhong Son, Wongi Seol
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2019-03-01
Edice:	Animal Cells and Systems
Témata:	LRRK2 G2019S mutation Parkisnon’s disease mitochondria microglia
On-line přístup:	http://dx.doi.org/10.1080/19768354.2019.1585948
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!