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The related EIF4G3 and EIF4G4 initiation factors from Leishmania: dissimilar modes of action during translation revealed by a comparative proteomic approach

Abstract Background The start of eukaryotic translation requires recruitment of messenger RNA (mRNA) through the action of the eukaryotic initiation factor 4F (eIF4F) complex. eIF4F is formed by joining of the eIF4G and eIF4E subunits and generally also requires the eIF4A helicase. In Leishmania inf...

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Principais autores: Stéphanny Sallomé Sousa Oliveira, Larissa Melo do Nascimento, Danielle Maria Nascimento Moura, Christian Robson de Souza Reis, Osvaldo Pompílio de Melo Neto
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-03-01
Serier:Parasites & Vectors
Fag:
Protein synthesis
mRNA translation
eIF4F complex
eIF4G
RNA binding protein
Mass spectrometry
Online adgang:https://doi.org/10.1186/s13071-026-07297-1
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